Duloxetine is an antidepressant, serotonin reuptake inhibitor and norepinephrine (noradrenaline). Weakly inhibits dopamine uptake, has no significant affinity for histamine, dopamine, cholinergic and adrenergic receptors. The mechanism of action is suppression of duloxetine reuptake of serotonin and norepinephrine (noradrenaline). Duloxetine has a central mechanism for the suppression of pain, which is primarily manifested by increased pain limit by syndrome of neuropathic etiology.
The recommended starting dose is 60 mg 1 time / day. If it is necessary, the daily dose 60 mg can be increased up to a maximum dose of 120 mg / day in 2 divided doses.
In patients with severe renal impairment, the initial dose should be 30 mg 1 time / day. In patients with impaired liver function the initial dose of the drug or the number of intakes should be reduced.
Using Duloxetine 60 mg with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Methylene Blue
Levitra is a drug for the treatment of erectile dysfunction that contains Vardenafil. This active ingredient selectively inhibits phosphodiesterase 5, which plays an important role in the physiological mechanism of penile erection.
The initial dose is 10 mg, which is taken in 10-25 minutes before sexual intercourse. The duration of action of levitra 20mg online is 8-12 hours. The maximum recommended dosing frequency - 1 time a day at a dose of 20 mg. Depending on the efficacy and tolerability, the dose may be increased to 20 mg or decreased to 5 mg per day.
Levitra is usually well tolerated. It was reported about rare cases of adverse effects in patients treated with Vardenafil. Especially, in clinical and post-marketing studies were noted side effects of Vardenafil:
Regarding the nervous system: convulsions, sleep disorders, dizziness, paresthesia, memory impairment, drowsiness, fatigue, headache.
Regarding the side of blood vessels, heart and blood system: vasodilation, angina, myocardial ischemia, blood pressure lability.
Regarding the respiratory system: runny nose, swelling of the nasal mucosa.